Selective inhibitors for JNK signalling: a potential targeted therapy in cancer

c-Jun N-terminal kinase (JNK) signalling regulates both cancer cell apoptosis and survival. Emerging evidence show that JNK promoted tumour progression is involved in various cancers, that include human pancreatic-, lung-, and breast cancer. The pro-survival JNK oncoprotein functions in a cell conte...

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Bibliographic Details
Main Authors: Qinghua Wu, Wenda Wu, Vesna Jacevic, Tanos C. C. Franca, Xu Wang, Kamil Kuca
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
jnk
Online Access:http://dx.doi.org/10.1080/14756366.2020.1720013