Design, synthesis and evaluation of biological activities of some novel anti-TB agents with bio-reducible functional group

Design, synthesis and evaluation of biological activities of some novel anti-TB agents with bio-reducible functional group

Introduction: With regard to the anti-mycobacterial activity of 2-pyrazinoic acid esters (POEs), recent studies have shown that both pyrazine core and alkyl part of POE interact with the fatty acid synthase type (I) (FAS (I)) precluding a complex formation between NADPH and FAS (I). Methods: Consid...

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Bibliographic Details
Main Authors: Hossein Khani-Meinagh, Hossein Mostafavi, Norbert Reiling, Majid Mahdavi, Gholamreza Zarrini
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2019-10-01
Series:BioImpacts
Subjects:
bioreducible center
cytotoxicity
fatty acid biosynthesis
mycobacterial growth inhibition
2-pyrazinoic acid ester
Online Access:https://bi.tbzmed.ac.ir/PDF/bi-9-199.pdf

Internet

https://bi.tbzmed.ac.ir/PDF/bi-9-199.pdf

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