Global Conformational Dynamics of HIV-1 Reverse Transcriptase Bound to Non-Nucleoside Inhibitors

Global Conformational Dynamics of HIV-1 Reverse Transcriptase Bound to Non-Nucleoside Inhibitors

HIV-1 Reverse Transcriptase (RT) is a multifunctional enzyme responsible for the transcription of the RNA genome of the HIV virus into DNA suitable for incorporation within the DNA of human host cells. Its crucial role in the viral life cycle has made it one of the major targets for antiretroviral d...

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Bibliographic Details
Main Authors: Peter V. Coveney, Paul Kellam, Benjamin A. Hall, David W. Wright
Format: Article
Language:English
Published: MDPI AG 2012-07-01
Series:Biology
Subjects:
HIV-1
reverse transcriptase
non-nucleoside reverse transcriptase inhibitor (NNRTI)
nevirapine
efavirenz
molecular dynamics
elastic network model
Online Access:http://www.mdpi.com/2079-7737/1/2/222

Internet

http://www.mdpi.com/2079-7737/1/2/222

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