Celastrol Alleviates Gamma Irradiation-Induced Damage by Modulating Diverse Inflammatory Mediators

Celastrol Alleviates Gamma Irradiation-Induced Damage by Modulating Diverse Inflammatory Mediators

The present study aimed to explore the possible radioprotective effects of celastrol and relevant molecular mechanisms in an in vitro cell and in vivo mouse models exposed to gamma radiation. Human keratinocytes (HaCaT) and foreskin fibroblast (BJ) cells were exposed to gamma radiation of 20 Gy, fol...

Full description

Bibliographic Details
Main Authors: Hong Wang, Kwang Seok Ahn, Sulaiman Ali Alharbi, Omar H. M. Shair, Frank Arfuso, Gautam Sethi, Arunachalam Chinnathambi, Feng Ru Tang
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
gamma radiation
celastrol
nf-κb
ros
in vitro
in vivo
Online Access:https://www.mdpi.com/1422-0067/21/3/1084

Internet

https://www.mdpi.com/1422-0067/21/3/1084

Similar Items