Overexpression of IκBα in cardiomyocytes alleviates hydrogen peroxide-induced apoptosis and autophagy by inhibiting NF-κB activation

Overexpression of IκBα in cardiomyocytes alleviates hydrogen peroxide-induced apoptosis and autophagy by inhibiting NF-κB activation

Abstract Background Inflammation and oxidative stress play predominant roles in the initiation and progression of ischaemia/reperfusion (I/R) injury, with nuclear factor kappa B (NF-κB) serving as a crucial mediator. Overexpression of the inhibitor of κB alpha (IκBα) gene is hypothesized to have pro...

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Bibliographic Details
Main Authors: Min Han, Xiao-Cui Chen, Ming-Hui Sun, Min-Tao Gai, Yi-Ning Yang, Xiao-Ming Gao, Xiang Ma, Bang-Dang Chen, Yi-Tong Ma
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Lipids in Health and Disease
Subjects:
Nuclear factor kappa B
Inhibitor of kappa B alpha
Apoptosis
Autophagy
Adeno-associated virus serotype 9
Oxidative stress
Online Access:http://link.springer.com/article/10.1186/s12944-020-01327-2

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http://link.springer.com/article/10.1186/s12944-020-01327-2

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