Difluoromethylornithine (DFMO), an Inhibitor of Polyamine Biosynthesis, and Antioxidant <i>N</i>-Acetylcysteine Potentiate Immune Response in Mice to the Recombinant Hepatitis C Virus NS5B Protein

Difluoromethylornithine (DFMO), an Inhibitor of Polyamine Biosynthesis, and Antioxidant <i>N</i>-Acetylcysteine Potentiate Immune Response in Mice to the Recombinant Hepatitis C Virus NS5B Protein

Hepatitis C virus (HCV) is one of the main triggers of chronic liver disease. Despite tremendous progress in the HCV field, there is still no vaccine against this virus. Potential vaccines can be based on its recombinant proteins. To increase the humoral and, especially, cellular immune response to...

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Bibliographic Details
Main Authors: Ekaterina I. Lesnova, Olga V. Masalova, Kristina Yu. Permyakova, Vyacheslav V. Kozlov, Tatyana N. Nikolaeva, Alexander V. Pronin, Vladimir T. Valuev-Elliston, Alexander V. Ivanov, Alla A. Kushch
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
hepatitis C virus (HCV)
nonstructural protein NS5B
<i>N</i>-acetylcysteine (NAC)
difluoromethylornithine (DFMO)
CpG ODN 1826
adjuvants
Online Access:https://www.mdpi.com/1422-0067/22/13/6892

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https://www.mdpi.com/1422-0067/22/13/6892

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