Self-microemulsifying drug delivery system for improving the bioavailability of huperzine A by lymphatic uptake

Self-microemulsifying drug delivery system for improving the bioavailability of huperzine A by lymphatic uptake

Huperzine A (Hup-A) is a poorly water-soluble drug with low oral bioavailability. A self-microemulsifying drug delivery system (SMEDDS) was used to enhance the oral bioavailability and lymphatic uptake and transport of Hup-A. A single-pass intestinal perfusion (SPIP) technique and a chylomicron flow...

Full description

Bibliographic Details
Main Authors: Fang Li, Rongfeng Hu, Bin Wang, Yun Gui, Gang Cheng, Song Gao, Lei Ye, Jihui Tang
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Huperzine A
Self-microemulsion
Drug delivery systems
SMEDDS
Bioavailability
Single-pass intestinal perfusion
Lymphatic transport
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383516303471

Internet

http://www.sciencedirect.com/science/article/pii/S2211383516303471

Similar Items