Ep400 deficiency in Schwann cells causes persistent expression of early developmental regulators and peripheral neuropathy

Ep400 deficiency in Schwann cells causes persistent expression of early developmental regulators and peripheral neuropathy

The Ep400 chromatin remodeler determines genomic distribution of variant histones. In the current study, the authors show that loss of Ep400 in Schwann cells leads to aberrant expression of developmental regulators, and a peripheral neuropathy phenotype.

Bibliographic Details
Main Authors: Franziska Fröb, Elisabeth Sock, Ernst. R. Tamm, Anna-Lena Saur, Simone Hillgärtner, Trevor J. Williams, Toshihiro Fujii, Rikiro Fukunaga, Michael Wegner
Format: Article
Language:English
Published: Nature Publishing Group 2019-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10287-w

Internet

https://doi.org/10.1038/s41467-019-10287-w

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