Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques

Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques

Inhibition of the metabolic enzyme ATP-citrate lyase can attenuate atherosclerosis by preventing dyslipidemia and potentially also by reducing macrophage-mediated inflammation. Here, the authors show that specific targeting of ACLY in macrophages results in more stable atherosclerotic plaques.

Bibliographic Details
Main Authors: Jeroen Baardman, Sanne G. S. Verberk, Saskia van der Velden, Marion J. J. Gijbels, Cindy P. P. A. van Roomen, Judith C. Sluimer, Jelle Y. Broos, Guillermo R. Griffith, Koen H. M. Prange, Michel van Weeghel, Soufyan Lakbir, Douwe Molenaar, Elisa Meinster, Annette E. Neele, Gijs Kooij, Helga E. de Vries, Esther Lutgens, Kathryn E. Wellen, Menno P. J. de Winther, Jan Van den Bossche
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20141-z

Internet

https://doi.org/10.1038/s41467-020-20141-z

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