The Ormdl genes regulate the sphingolipid synthesis pathway to ensure proper myelination and neurologic function in mice

The Ormdl genes regulate the sphingolipid synthesis pathway to ensure proper myelination and neurologic function in mice

Sphingolipids are membrane and bioactive lipids that are required for many aspects of normal mammalian development and physiology. However, the importance of the regulatory mechanisms that control sphingolipid levels in these processes is not well understood. The mammalian ORMDL proteins (ORMDL1, 2...

Full description

Bibliographic Details
Main Authors: Benjamin A Clarke, Saurav Majumder, Hongling Zhu, Y Terry Lee, Mari Kono, Cuiling Li, Caroline Khanna, Hailey Blain, Ronit Schwartz, Vienna L Huso, Colleen Byrnes, Galina Tuymetova, Teresa M Dunn, Maria L Allende, Richard L Proia
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-12-01
Series:eLife
Subjects:
sphingolipids
myelination
mouse models
metabolism
Online Access:https://elifesciences.org/articles/51067

Internet

https://elifesciences.org/articles/51067

Similar Items