Mcl-1 Inhibition: Managing Malignancy in Multiple Myeloma

Mcl-1 Inhibition: Managing Malignancy in Multiple Myeloma

Multiple myeloma (MM) is a plasma cells neoplasm. The overexpression of Bcl-2 family proteins, particularly myeloid cell leukemia 1 (Mcl-1), plays a critical role in the pathogenesis of MM. The overexpression of Mcl-1 is associated with drug resistance and overall poor prognosis of MM. Thus, inhibit...

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Bibliographic Details
Main Authors: Omar S. Al-Odat, Max von Suskil, Robert J. Chitren, Weam O. Elbezanti, Sandeep K. Srivastava, Tulin Budak-Alpddogan, Subash C. Jonnalagadda, Bharat B. Aggarwal, Manoj Pandey
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pharmacology
Subjects:
multiple myeloma
drug resistant
Mcl-1
Bcl-2 homology 3 mimetics
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.699629/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.699629/full

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