Transcription Factor Bcl11b Controls Effector and Memory CD8 T cell Fate Decision and Function During Poxvirus Infection

Transcription Factor Bcl11b Controls Effector and Memory CD8 T cell Fate Decision and Function During Poxvirus Infection

CD8+ T cells play an important role in host resistance to many viral infections, but the underlying transcriptional mechanisms governing their differentiation and functionality remain poorly defined. By using a highly virulent systemic and respiratory poxvirus infection in mice, we show that the tra...

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Bibliographic Details
Main Authors: Georges Abboud, Jessica Stanfield, Vikas Tahiliani, Pritesh Desai, Tarun Edgar Hutchinson, kyle J Lorentsen, Jonathan J Cho, Dorina Avram, Shahram Salek-Ardakani
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Immunology
Subjects:
Lung
Memory
Transcription Factors
Viruses
T cells
mouse models
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00425/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00425/full

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