Mice Lacking the Matrilin Family of Extracellular Matrix Proteins Develop Mild Skeletal Abnormalities and Are Susceptible to Age-Associated Osteoarthritis

Mice Lacking the Matrilin Family of Extracellular Matrix Proteins Develop Mild Skeletal Abnormalities and Are Susceptible to Age-Associated Osteoarthritis

Matrilins (MATN1, MATN2, MATN3 and MATN4) are adaptor proteins of the cartilage extracellular matrix (ECM), which bridge the collagen II and proteoglycan networks. In humans, dominant-negative mutations in MATN3 lead to various forms of mild chondrodysplasias. However, single or double matrilin knoc...

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Bibliographic Details
Main Authors: Ping Li, Lutz Fleischhauer, Claudia Nicolae, Carina Prein, Zsuzsanna Farkas, Maximilian Michael Saller, Wolf Christian Prall, Raimund Wagener, Juliane Heilig, Anja Niehoff, Hauke Clausen-Schaumann, Paolo Alberton, Attila Aszodi
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:International Journal of Molecular Sciences
Subjects:
matrilin
cartilage
bone development
articular cartilage
osteoarthritis
Online Access:https://www.mdpi.com/1422-0067/21/2/666

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https://www.mdpi.com/1422-0067/21/2/666

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