Targeting STAT3 Abrogates Tim-3 Upregulation of Adaptive Resistance to PD-1 Blockade on Regulatory T Cells of Melanoma

Targeting STAT3 Abrogates Tim-3 Upregulation of Adaptive Resistance to PD-1 Blockade on Regulatory T Cells of Melanoma

BackgroundLess than 20% of melanoma patients respond to programmed cell death-1 (PD-1) blockade immunotherapies. Thus, it is crucial to understand the dynamic changes in the tumor microenvironment (TME) after PD-1 blockade, for developing immunotherapy efficacy.MethodsA genomic analysis was conducte...

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Bibliographic Details
Main Authors: Lili Huang, Yu Xu, Juemin Fang, Weixing Liu, Jianhua Chen, Zhuqing Liu, Qing Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
regulatory T cells
Tim-3
melanoma
anti-PD-1 therapy
STAT3
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.654749/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.654749/full

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