HIF-1α and Pro-Inflammatory Signaling Improves the Immunomodulatory Activity of MSC-Derived Extracellular Vesicles

HIF-1α and Pro-Inflammatory Signaling Improves the Immunomodulatory Activity of MSC-Derived Extracellular Vesicles

Despite the strong evidence for the immunomodulatory activity of mesenchymal stromal cells (MSCs), clinical trials have so far failed to clearly show benefit, likely reflecting methodological shortcomings and lack of standardization. MSC-mediated tissue repair is commonly believed to occur in a para...

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Bibliographic Details
Main Authors: Marta Gómez-Ferrer, Estela Villanueva-Badenas, Rafael Sánchez-Sánchez, Christian M. Sánchez-López, Maria Carmen Baquero, Pilar Sepúlveda, Akaitz Dorronsoro
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
mesenchymal stromal cells
T-cells
extracellular vesicles
hypoxia-inducible factor 1-alpha
immunomodulation
Online Access:https://www.mdpi.com/1422-0067/22/7/3416

Internet

https://www.mdpi.com/1422-0067/22/7/3416

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