The snoRNA target of t(4;14) in multiple myeloma regulates ribosome biogenesis

The snoRNA target of t(4;14) in multiple myeloma regulates ribosome biogenesis

Abstract The orphan small nucleolar RNA (snoRNA) ACA11 is overexpressed as a result of the t(4;14) chromosomal translocation in multiple myeloma (MM), increases reactive oxygen species, and drives cell proliferation. Like other snoRNAs, ACA11 is predominantly localized to a sub‐nuclear organelle, th...

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Bibliographic Details
Main Authors: Vanessa Oliveira, Nitin Mahajan, Melissa L. Bates, Chakrapani Tripathi, Kyusik Q. Kim, Hani S. Zaher, Leonard B. Maggi Jr, Michael H. Tomasson
Format: Article
Language:English
Published: Wiley 2019-07-01
Series:FASEB BioAdvances
Subjects:
chromosomal translocation
hematological malignancy
protein synthesis
reactive oxygen species
Online Access:https://doi.org/10.1096/fba.2018-00075

Internet

https://doi.org/10.1096/fba.2018-00075

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