Arf6 controls retromer traffic and intracellular cholesterol distribution via a phosphoinositide-based mechanism

Arf6 controls retromer traffic and intracellular cholesterol distribution via a phosphoinositide-based mechanism

The small GTPase Arf6 regulates intracellular transport, phosphoinositide signalling and cholesterol homeostasis. Here, Marquer et al. show that loss of Arf6 causes cholesterol accumulation in endosomes due to defects in phosphoinositide-dependent retromer-mediated trafficking of CI-M6PR and NPC2.

Bibliographic Details
Main Authors: Catherine Marquer, Huasong Tian, Julie Yi, Jayson Bastien, Claudia Dall'Armi, YoungJoo Yang-Klingler, Bowen Zhou, Robin Barry Chan, Gilbert Di Paolo
Format: Article
Language:English
Published: Nature Publishing Group 2016-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11919

Internet

https://doi.org/10.1038/ncomms11919

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