Measuring airway surface liquid depth in ex vivo mouse airways by x-ray imaging for the assessment of cystic fibrosis airway therapies.

Measuring airway surface liquid depth in ex vivo mouse airways by x-ray imaging for the assessment of cystic fibrosis airway therapies.

In the airways of those with cystic fibrosis (CF), the leading pathophysiological hypothesis is that an ion channel defect results in a relative decrease in airway surface liquid (ASL) volume, producing thick and sticky mucus that facilitates the establishment and progression of early fatal lung dis...

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Bibliographic Details
Main Authors: Kaye S Morgan, Martin Donnelley, David M Paganin, Andreas Fouras, Naoto Yagi, Yoshio Suzuki, Akihisa Takeuchi, Kentaro Uesugi, Richard C Boucher, David W Parsons, Karen K W Siu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3559635?pdf=render

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http://europepmc.org/articles/PMC3559635?pdf=render

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