A population of innate myelolymphoblastoid effector cell expanded by inactivation of mTOR complex 1 in mice

A population of innate myelolymphoblastoid effector cell expanded by inactivation of mTOR complex 1 in mice

Adaptive autoimmunity is restrained by controlling population sizes and pathogenicity of harmful clones, while innate destruction is controlled at effector phase. We report here that deletion of Rptor in mouse hematopoietic stem/progenitor cells causes self-destructive innate immunity by massively i...

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Bibliographic Details
Main Authors: Fei Tang, Peng Zhang, Peiying Ye, Christopher A Lazarski, Qi Wu, Ingrid L Bergin, Timothy P Bender, Michael N Hall, Ya Cui, Liguo Zhang, Taijiao Jiang, Yang Liu, Pan Zheng
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-12-01
Series:eLife
Subjects:
hemotopoiesis
TSC-mTOR signaling
mTORC1
innate immunity
inflammation
immune tolerance
Online Access:https://elifesciences.org/articles/32497

Internet

https://elifesciences.org/articles/32497

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