Unbiased proteomic mapping of the LINE-1 promoter using CRISPR Cas9

Unbiased proteomic mapping of the LINE-1 promoter using CRISPR Cas9

Abstract Background The autonomous retroelement Long Interspersed Element-1 (LINE-1) mobilizes though a copy and paste mechanism using an RNA intermediate (retrotransposition). Throughout human evolution, around 500,000 LINE-1 sequences have accumulated in the genome. Most of these sequences belong...

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Bibliographic Details
Main Authors: Erica M. Briggs, Paolo Mita, Xiaoji Sun, Susan Ha, Nikita Vasilyev, Zev R. Leopold, Evgeny Nudler, Jef D. Boeke, Susan K. Logan
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Mobile DNA
Subjects:
LINE-1
Transcriptional regulation
Cancer
C-BERST
CRISPR Cas9 Restricted Spatial Tagging
Online Access:https://doi.org/10.1186/s13100-021-00249-9

Internet

https://doi.org/10.1186/s13100-021-00249-9

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