Chronic nicotine improves cognitive and social impairment in mice overexpressing wild type α-synuclein

Chronic nicotine improves cognitive and social impairment in mice overexpressing wild type α-synuclein

In addition to dopaminergic and motor deficits, patients with Parkinson's disease (PD) suffer from non-motor symptoms, including early cognitive and social impairment, that do not respond well to dopaminergic therapy. Cholinergic deficits may contribute to these problems, but cholinesterase inh...

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Bibliographic Details
Main Authors: Sudhakar R. Subramaniam, Iddo Magen, Nicholas Bove, Chunni Zhu, Vincent Lemesre, Garima Dutta, Chris Jean Elias, Henry A. Lester, Marie-Francoise Chesselet
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Mouse model
α-synuclein
Nicotine
Motor deficits
Cognitive deficits
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118301566

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http://www.sciencedirect.com/science/article/pii/S0969996118301566

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