Targeting Parthanatos in Ischemic Stroke

Targeting Parthanatos in Ischemic Stroke

Parthanatos is a cell death signaling pathway in which excessive oxidative damage to DNA leads to over-activation of poly(ADP-ribose) polymerase (PARP). PARP then generates the formation of large poly(ADP-ribose) polymers that induce the release of apoptosis-inducing factor from the outer mitochondr...

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Bibliographic Details
Main Authors: Raymond C. Koehler, Valina L. Dawson, Ted M. Dawson
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Neurology
Subjects:
cerebral ischemia
neuroinflammation
parthanatos
poly(ADP ribose) polymerase
stroke
middle cerebral artery occlusion
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2021.662034/full

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https://www.frontiersin.org/articles/10.3389/fneur.2021.662034/full

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