A Conjugation Strategy to Modulate Antigen Binding and FcRn Interaction Leads to Improved Tumor Targeting and Radioimmunotherapy Efficacy with an Antibody Targeting Prostate-Specific Antigen

A Conjugation Strategy to Modulate Antigen Binding and FcRn Interaction Leads to Improved Tumor Targeting and Radioimmunotherapy Efficacy with an Antibody Targeting Prostate-Specific Antigen

Background: The humanized monoclonal antibody (mAb) hu5A10 specifically targets and internalizes prostate cancer cells by binding to prostate specific antigen (PSA). Preclinical evaluations have shown that hu5A10 is an excellent vehicle for prostate cancer (PCa) radiotheranostics. We studied the imp...

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Bibliographic Details
Main Authors: Oskar Vilhelmsson Timmermand, Anders Örbom, Mohamed Altai, Wahed Zedan, Bo Holmqvist, Marcella Safi, Thuy A. Tran, Sven-Erik Strand, Joanna Strand
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
prostate cancer
FcRn
radionuclide therapy
hu5A10
PSA
Online Access:https://www.mdpi.com/2072-6694/13/14/3469

Internet

https://www.mdpi.com/2072-6694/13/14/3469

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