Bazedoxifene inhibits sustained STAT3 activation and increases survival in GBM

Bazedoxifene inhibits sustained STAT3 activation and increases survival in GBM

An important factor correlated with poor survival in glioblastoma (GBM) is the aberrant and persistent activation of STAT3, a critical transcription factor that regulates multiple genes with key roles in cell survival, proliferation, resistance to chemotherapy, and stem cell maintenance. The Interle...

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Bibliographic Details
Main Authors: Samantha M. Wightman, Tyler J. Alban, Xing Chen, Justin D. Lathia, Yuxin Wang, George R. Stark
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Translational Oncology
Subjects:
Glioblastoma
IL6
STAT3
Bazedoxifene
Glioma stem cells
Cancer stem cells
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523321001844

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http://www.sciencedirect.com/science/article/pii/S1936523321001844

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