Bazedoxifene inhibits sustained STAT3 activation and increases survival in GBM
An important factor correlated with poor survival in glioblastoma (GBM) is the aberrant and persistent activation of STAT3, a critical transcription factor that regulates multiple genes with key roles in cell survival, proliferation, resistance to chemotherapy, and stem cell maintenance. The Interle...
Main Authors: | Samantha M. Wightman, Tyler J. Alban, Xing Chen, Justin D. Lathia, Yuxin Wang, George R. Stark |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2021-11-01
|
Series: | Translational Oncology |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523321001844 |
Similar Items
-
Bazedoxifene as a novel GP130 inhibitor for Colon Cancer therapy
by: Jia Wei, et al.
Published: (2019-02-01) -
Bazedoxifene Attenuates Abdominal Aortic Aneurysm Formation via Downregulation of Interleukin-6/Glycoprotein 130/Signal Transducer and Activator of Transcription 3 Signaling Pathway in Apolipoprotein E–Knockout Mice
by: Dan Yan, et al.
Published: (2020-04-01) -
STAT3 Inhibitor ODZ10117 Suppresses Glioblastoma Malignancy and Prolongs Survival in a Glioblastoma Xenograft Model
by: Byung-Hak Kim, et al.
Published: (2020-03-01) -
Effects of conjugated estrogen and bazedoxifene on hemostasis and thrombosis in mice
by: Emmanuelle Noirrit, et al.
Published: (2019-06-01) -
Bazedoxifene Suppresses Intracellular Mycobacterium tuberculosis Growth by Enhancing Autophagy
by: Qi Ouyang, et al.
Published: (2020-04-01)