Serum amyloid A primes microglia for ATP-dependent interleukin-1β release

Serum amyloid A primes microglia for ATP-dependent interleukin-1β release

Abstract Background Acute-phase response is a systemic reaction to environmental/inflammatory insults and involves production of acute-phase proteins, including serum amyloid A (SAA). Interleukin-1β (IL-1β), a master regulator of neuroinflammation produced by activated inflammatory cells of the myel...

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Bibliographic Details
Main Authors: Laura Facci, Massimo Barbierato, Morena Zusso, Stephen D. Skaper, Pietro Giusti
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
Serum amyloid A
Interleukin-1β
Toll-like receptor
P2X purinoceptor 7
NLRP3 inflammasome
Online Access:http://link.springer.com/article/10.1186/s12974-018-1205-6

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http://link.springer.com/article/10.1186/s12974-018-1205-6

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