Lymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions

Lymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions

Innate T cells (ITC) contain many subsets and are poised to promptly respond to antigens and pathogens, but how this poised state is maintained is still unclear. Here the authors perform single-cell RNA-seq to align the various ITC subsets along an ‘innateness gradient’ that is associated with chang...

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Bibliographic Details
Main Authors: Maria Gutierrez-Arcelus, Nikola Teslovich, Alex R. Mola, Rafael B. Polidoro, Aparna Nathan, Hyun Kim, Susan Hannes, Kamil Slowikowski, Gerald F. M. Watts, Ilya Korsunsky, Michael B. Brenner, Soumya Raychaudhuri, Patrick J. Brennan
Format: Article
Language:English
Published: Nature Publishing Group 2019-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-08604-4

Internet

https://doi.org/10.1038/s41467-019-08604-4

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