Metabolite identification, tissue distribution, excretion and preclinical pharmacokinetic studies of ET-26-HCl, a new analogue of etomidate

Metabolite identification, tissue distribution, excretion and preclinical pharmacokinetic studies of ET-26-HCl, a new analogue of etomidate

ET-26-HCl, a novel anaesthetic agent with promising pharmacological properties, lacks extensive studies on pharmacokinetics and disposition in vitro and in vivo. In this study, we investigated the metabolic stability, metabolite production and plasma protein binding (PPB) of ET-26-HCl along with its...

Full description

Bibliographic Details
Main Authors: Lu Yu, Xu Chen, Wen Sheng Zhang, Liang Zheng, Wen Wen Xu, Ming Yu Xu, Xue Hua Jiang, Ling Wang
Format: Article
Language:English
Published: The Royal Society 2020-02-01
Series:Royal Society Open Science
Subjects:
et-26-hcl
metabolites
plasma protein binding
pharmacokinetics
tissue distribution
excretion
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.191666

Internet

https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.191666

Similar Items