Widespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins

Widespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins

Some phages carry genes coding for anti-CRISPR (Acr) proteins that interfere with the activity of bacterial CRISPR-Cas systems. Here, Hynes et al. characterize a new Acr family from streptococcal phages and investigate its potential in genome-editing applications.

Bibliographic Details
Main Authors: Alexander P. Hynes, Geneviève M. Rousseau, Daniel Agudelo, Adeline Goulet, Beatrice Amigues, Jeremy Loehr, Dennis A. Romero, Christophe Fremaux, Philippe Horvath, Yannick Doyon, Christian Cambillau, Sylvain Moineau
Format: Article
Language:English
Published: Nature Publishing Group 2018-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05092-w

Internet

https://doi.org/10.1038/s41467-018-05092-w

Similar Items