Widespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins
Some phages carry genes coding for anti-CRISPR (Acr) proteins that interfere with the activity of bacterial CRISPR-Cas systems. Here, Hynes et al. characterize a new Acr family from streptococcal phages and investigate its potential in genome-editing applications.
Bibliographic Details
Main Authors: |
Alexander P. Hynes,
Geneviève M. Rousseau,
Daniel Agudelo,
Adeline Goulet,
Beatrice Amigues,
Jeremy Loehr,
Dennis A. Romero,
Christophe Fremaux,
Philippe Horvath,
Yannick Doyon,
Christian Cambillau,
Sylvain Moineau |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2018-07-01
|
Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-018-05092-w
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