Ten-eleven translocation protein 1 modulates medulloblastoma progression

Ten-eleven translocation protein 1 modulates medulloblastoma progression

Abstract Background Medulloblastoma (MB) is the most common malignant pediatric brain tumor that originates in the cerebellum and brainstem. Frequent somatic mutations and deregulated expression of epigenetic regulators in MB highlight the substantial role of epigenetic alterations. 5-hydroxymethylc...

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Bibliographic Details
Main Authors: Hyerim Kim, Yunhee Kang, Yujing Li, Li Chen, Li Lin, Nicholas D. Johnson, Dan Zhu, M. Hope Robinson, Leon McSwain, Benjamin G. Barwick, Xianrui Yuan, Xinbin Liao, Jie Zhao, Zhiping Zhang, Qiang Shu, Jianjun Chen, Emily G. Allen, Anna M. Kenney, Robert C. Castellino, Erwin G. Van Meir, Karen N. Conneely, Paula M. Vertino, Peng Jin, Jian Li
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Genome Biology
Subjects:
Medulloblastoma
5-hydroxymethylcytosine
TET1
Stem-like property
NANOG
PDGF signaling pathway
Online Access:https://doi.org/10.1186/s13059-021-02352-9

Internet

https://doi.org/10.1186/s13059-021-02352-9

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