Delayed Azithromycin Treatment Improves Recovery After Mouse Spinal Cord Injury

Delayed Azithromycin Treatment Improves Recovery After Mouse Spinal Cord Injury

After spinal cord injury (SCI), macrophages infiltrate into the lesion and can adopt a wide spectrum of activation states. However, the pro-inflammatory, pathological macrophage activation state predominates and contributes to progressive neurodegeneration. Azithromycin (AZM), an FDA approved macrol...

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Bibliographic Details
Main Authors: Timothy J. Kopper, Katelyn E. McFarlane, William M. Bailey, Michael B. Orr, Bei Zhang, John C. Gensel
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
anti-inflammatory
monocyte
microglia
M1
M2
alternatively-activated
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00490/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00490/full

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