Phenotypic characterization of a Csf1r haploinsufficient mouse model of adult-onset leukodystrophy with axonal spheroids and pigmented glia (ALSP)

Phenotypic characterization of a Csf1r haploinsufficient mouse model of adult-onset leukodystrophy with axonal spheroids and pigmented glia (ALSP)

Mutations in the colony stimulating factor-1 receptor (CSF1R) that abrogate the expression of the affected allele or lead to the expression of mutant receptor chains devoid of kinase activity have been identified in both familial and sporadic cases of ALSP. To determine the validity of the Csf1r het...

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Bibliographic Details
Main Authors: Violeta Chitu, Solen Gokhan, Maria Gulinello, Craig A. Branch, Madhuvati Patil, Ranu Basu, Corrina Stoddart, Mark F. Mehler, E. Richard Stanley
Format: Article
Language:English
Published: Elsevier 2015-02-01
Series:Neurobiology of Disease
Subjects:
Leukodystrophy
ALSP
HDLS
CSF-1R
Microglia
Dysmyelination
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114003726

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http://www.sciencedirect.com/science/article/pii/S0969996114003726

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