Expansion of circulating peripheral TIGIT+CD226+ CD4 T cells with enhanced effector functions in dermatomyositis

Expansion of circulating peripheral TIGIT+CD226+ CD4 T cells with enhanced effector functions in dermatomyositis

Abstract Background T cell Ig and ITIM domain (TIGIT)/CD226 pathway has a critical role in regulating T cell responses and has come to the forefront in cancer as a promising immunotherapeutic target. However, its role in autoimmune diseases is just beginning to be elucidated. Dermatomyositis (DM) is...

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Bibliographic Details
Main Authors: Wenli Li, Chuiwen Deng, Hanbo Yang, Xin Lu, Shanshan Li, Xia Liu, Fang Chen, Lida Chen, Xiaoming Shu, Lu Zhang, Qingyan Liu, Guochun Wang, Qinglin Peng
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Arthritis Research & Therapy
Subjects:
T cell Ig and ITIM domain
CD226
Dermatomyositis
Co-inhibitory receptor
Co-stimulatory receptor
Online Access:https://doi.org/10.1186/s13075-020-02397-4

Internet

https://doi.org/10.1186/s13075-020-02397-4

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