Tyrosinase-Cre-Mediated Deletion of the Autophagy Gene Atg7 Leads to Accumulation of the RPE65 Variant M450 in the Retinal Pigment Epithelium of C57BL/6 Mice.

Tyrosinase-Cre-Mediated Deletion of the Autophagy Gene Atg7 Leads to Accumulation of the RPE65 Variant M450 in the Retinal Pigment Epithelium of C57BL/6 Mice.

Targeted gene knockout mouse models have helped to identify roles of autophagy in many tissues. Here, we investigated the retinal pigment epithelium (RPE) of Atg7f/f Tyr-Cre mice (on a C57BL/6 background), in which Cre recombinase is expressed under the control of the tyrosinase promoter to delete t...

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Bibliographic Details
Main Authors: Supawadee Sukseree, Ying-Ting Chen, Maria Laggner, Florian Gruber, Valérie Petit, Ionela-Mariana Nagelreiter, Veronika Mlitz, Heidemarie Rossiter, Andreas Pollreisz, Ursula Schmidt-Erfurth, Lionel Larue, Erwin Tschachler, Leopold Eckhart
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4990303?pdf=render

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http://europepmc.org/articles/PMC4990303?pdf=render

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