Restoration of regulatory B cell deficiency following alemtuzumab therapy in patients with relapsing multiple sclerosis

Restoration of regulatory B cell deficiency following alemtuzumab therapy in patients with relapsing multiple sclerosis

Abstract Background Regulatory B cells (Bregs), which protect from autoimmunity, are deficient in multiple sclerosis (MS). Novel regulatory B cell subsets CD19+CD24hiCD38hi cells and CD19+PD-L1hi cells, with disparate regulatory mechanisms have been defined. Alemtuzumab provides a long-lasting suppr...

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Bibliographic Details
Main Authors: Yeseul Kim, Gayoung Kim, Hyun-June Shin, Jae-Won Hyun, Su-Hyun Kim, Eunjig Lee, Ho Jin Kim
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Journal of Neuroinflammation
Subjects:
Multiple sclerosis
Regulatory B cells
Alemtuzumab
Relapse
Online Access:http://link.springer.com/article/10.1186/s12974-018-1334-y

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http://link.springer.com/article/10.1186/s12974-018-1334-y

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