OGT (O-GlcNAc Transferase) Selectively Modifies Multiple Residues Unique to Lamin A

OGT (O-GlcNAc Transferase) Selectively Modifies Multiple Residues Unique to Lamin A

The LMNA gene encodes lamins A and C with key roles in nuclear structure, signaling, gene regulation, and genome integrity. Mutations in LMNA cause over 12 diseases (‘laminopathies’). Lamins A and C are identical for their first 566 residues. However, they form separate filaments...

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Bibliographic Details
Main Authors: Dan N. Simon, Amanda Wriston, Qiong Fan, Jeffrey Shabanowitz, Alyssa Florwick, Tejas Dharmaraj, Sherket B. Peterson, Yosef Gruenbaum, Cathrine R. Carlson, Line M. Grønning-Wang, Donald F. Hunt, Katherine L. Wilson
Format: Article
Language:English
Published: MDPI AG 2018-05-01
Series:Cells
Subjects:
lamin
nuclear lamina
O-GlcNAcylation
O-linked N-acetylglucosamine (O-GlcNAc) Transferase (OGT)
Online Access:http://www.mdpi.com/2073-4409/7/5/44

Internet

http://www.mdpi.com/2073-4409/7/5/44

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