Teaming Up for Trouble: Cancer Cells, Transforming Growth Factor-β1 Signaling and the Epigenetic Corruption of Stromal Naïve Fibroblasts

Teaming Up for Trouble: Cancer Cells, Transforming Growth Factor-β1 Signaling and the Epigenetic Corruption of Stromal Naïve Fibroblasts

It is well recognized that cancer cells subvert the phenotype of stromal naïve fibroblasts and instruct the neighboring cells to sustain their growth agenda. The mechanisms underpinning the switch of fibroblasts to cancer-associated fibroblasts (CAFs) are the focus of intense investigation. One of t...

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Bibliographic Details
Main Authors: Sergio Lamprecht, Ina Sigal-Batikoff, Shraga Shany, Naim Abu-Freha, Eduard Ling, George J. Delinasios, Keren Moyal-Atias, John G. Delinasios, Alexander Fich
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Cancers
Subjects:
cancer
tumor microenvironment
transforming growth factor-β
epigenetics
colorectal cancer
cancer-associated fibroblasts
Online Access:http://www.mdpi.com/2072-6694/10/3/61

Internet

http://www.mdpi.com/2072-6694/10/3/61

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