Synthesis and Biological Evaluation of Novel 2-Methoxypyridylamino-Substituted Riminophenazine Derivatives as Antituberculosis Agents

Synthesis and Biological Evaluation of Novel 2-Methoxypyridylamino-Substituted Riminophenazine Derivatives as Antituberculosis Agents

Clofazimine, a member of the riminophenazine class, is one of the few antibiotics that are still active against multidrug-resistant Mycobacterium tuberculosis (M. tuberculosis). However, the clinical utility of this agent is limited by its undesirable physicochemical properties and skin pigmentation...

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Bibliographic Details
Main Authors: Dongfeng Zhang, Yang Liu, Chunlin Zhang, Hao Zhang, Bin Wang, Jian Xu, Lei Fu, Dali Yin, Christopher B. Cooper, Zhenkun Ma, Yu Lu, Haihong Huang
Format: Article
Language:English
Published: MDPI AG 2014-04-01
Series:Molecules
Subjects:
clofazimine
antituberculosis activity
2-methoxypyridylamino-substituted riminophenazines
skin discoloration
Online Access:http://www.mdpi.com/1420-3049/19/4/4380

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http://www.mdpi.com/1420-3049/19/4/4380

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