Epigenetic Regulation via Altered Histone Acetylation Results in Suppression of Mast Cell Function and Mast Cell-Mediated Food Allergic Responses

Epigenetic Regulation via Altered Histone Acetylation Results in Suppression of Mast Cell Function and Mast Cell-Mediated Food Allergic Responses

Mast cells are highly versatile cells that perform a variety of functions depending on the immune trigger, context of activation, and cytokine stimulus. Antigen-mediated mast cell responses are regulated by transcriptional processes that result in the induction of numerous genes contributing to mast...

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Bibliographic Details
Main Authors: Dylan Krajewski, Edwin Kaczenski, Jeffrey Rovatti, Stephanie Polukort, Chelsea Thompson, Catherine Dollard, Jennifer Ser-Dolansky, Sallie S. Schneider, Shannon R. M. Kinney, Clinton B. Mathias
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
mast cells
food allergy
trichostatin A
histone deacetylase (HDAC) inhibitors
epigenetics
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02414/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02414/full

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