Aurora-B knockdown inhibits osteosarcoma metastasis by inducing autophagy via the mTOR/ULK1 pathway

Aurora-B knockdown inhibits osteosarcoma metastasis by inducing autophagy via the mTOR/ULK1 pathway

Abstract Background Autophagy plays an essential role in metastasis of malignancies. Although our studies showed that Aurora-B facilitate pulmonary metastasis in OS, the mechanism of Aurora-B kinase on autophagy and metastasis in OS has not been explored. Methods Clinical-pathological parameters and...

Full description

Bibliographic Details
Main Authors: Xin Wu, Jia-ming Liu, Hong-hai Song, Qi-kun Yang, Hui Ying, Wei-lai Tong, Yang Zhou, Zhi-li Liu
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Cancer Cell International
Subjects:
Osteosarcoma
Aurora-B
The mTOR/ULK1 pathway
Autophagy
Metastasis
Online Access:https://doi.org/10.1186/s12935-020-01674-1

Internet

https://doi.org/10.1186/s12935-020-01674-1

Similar Items