Towards Controlling the Glycoform: A Model Framework Linking Extracellular Metabolites to Antibody Glycosylation

Towards Controlling the Glycoform: A Model Framework Linking Extracellular Metabolites to Antibody Glycosylation

Glycoproteins represent the largest group of the growing number of biologically-derived medicines. The associated glycan structures and their distribution are known to have a large impact on pharmacokinetics. A modelling framework was developed to provide a link from the extracellular environment an...

Full description

Bibliographic Details
Main Authors: Philip M. Jedrzejewski, Ioscani Jimenez del Val, Antony Constantinou, Anne Dell, Stuart M. Haslam, Karen M. Polizzi, Cleo Kontoravdi
Format: Article
Language:English
Published: MDPI AG 2014-03-01
Series:International Journal of Molecular Sciences
Subjects:
metabolic modelling
nucleotide sugars
antibody glycosylation
Online Access:http://www.mdpi.com/1422-0067/15/3/4492

Internet

http://www.mdpi.com/1422-0067/15/3/4492

Similar Items