β-Galactoside-mediated tissue organization during islet reconstitution

We have previously reported that multi-cellular heteroaggregates comprising murine pancreatic α (αTC1.6) and β (MIN6-m9) cell lines spontaneously acquired islet-like architecture and displayed higher insulin secretion rates. However, the mechanisms of self-organization remain unclear. The objective...

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Bibliographic Details
Main Authors: Sae Kamitori, Yasuhiro Ozeki, Nobuhiko Kojima
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Regenerative Therapy
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2352320416000109