HIF-1alpha and HIF-2alpha are differentially activated in distinct cell populations in retinal ischaemia.
Hypoxia plays a key role in ischaemic and neovascular disorders of the retina. Cellular responses to oxygen are mediated by hypoxia-inducible transcription factors (HIFs) that are stabilised in hypoxia and induce the expression of a diverse range of genes. The purpose of this study was to define the...
Main Authors: | , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2010-06-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC2885428?pdf=render |