Contextual cues from cancer cells govern cancer-associated fibroblast heterogeneity

Contextual cues from cancer cells govern cancer-associated fibroblast heterogeneity

Summary: Cancer cells function as primary architects of the tumor microenvironment. However, the molecular features of cancer cells that govern stromal cell phenotypes remain unclear. Here, we show that cancer-associated fibroblast (CAF) heterogeneity is driven by lung adenocarcinoma (LUAD) cells at...

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Bibliographic Details
Main Authors: Neus Bota-Rabassedas, Priyam Banerjee, Yichi Niu, Wenjian Cao, Jiayi Luo, Yuanxin Xi, Xiaochao Tan, Kuanwei Sheng, Young-Ho Ahn, Sieun Lee, Edwin Roger Parra, Jaime Rodriguez-Canales, Jacob Albritton, Michael Weiger, Xin Liu, Hou-Fu Guo, Jiang Yu, B. Leticia Rodriguez, Joshua J.A. Firestone, Barbara Mino, Chad J. Creighton, Luisa M. Solis, Pamela Villalobos, Maria Gabriela Raso, Daniel W. Sazer, Don L. Gibbons, William K. Russell, Gregory D. Longmore, Ignacio I. Wistuba, Jing Wang, Harold A. Chapman, Jordan S. Miller, Chenghang Zong, Jonathan M. Kurie
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Cell Reports
Subjects:
cancer-associated fibroblast
EMT
metastasis
lung cancer
tumor microenvironment
microRNA
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721003235

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http://www.sciencedirect.com/science/article/pii/S2211124721003235

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