Shiga Toxin 2a Binds to Complement Components C3b and C5 and Upregulates Their Gene Expression in Human Cell Lines

Shiga Toxin 2a Binds to Complement Components C3b and C5 and Upregulates Their Gene Expression in Human Cell Lines

Enterohemorrhagic <i>Escherichia coli</i> (EHEC) infections can cause EHEC-associated hemolytic uremic syndrome (eHUS) via its main virulent factor, Shiga toxins (Stxs). Complement has been reported to be involved in the progression of eHUS. The aim of this study was to investigate the i...

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Bibliographic Details
Main Authors: Sára Kellnerová, Sneha Chatterjee, Rafael Bayarri-Olmos, Louise Justesen, Heribert Talasz, Wilfried Posch, Samyr Kenno, Peter Garred, Dorothea Orth-Höller, Marco Grasse, Reinhard Würzner
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Toxins
Subjects:
Shiga toxin 2a
hemolytic uremic syndrome
C3
C5
intracellular complement
HK-2
Online Access:https://www.mdpi.com/2072-6651/13/1/8

Internet

https://www.mdpi.com/2072-6651/13/1/8

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