Exploring the Genotype–Phenotype Correlation in GBA-Parkinson Disease: Clinical Aspects, Biomarkers, and Potential Modifiers

Exploring the Genotype–Phenotype Correlation in GBA-Parkinson Disease: Clinical Aspects, Biomarkers, and Potential Modifiers

Variants in the glucocerebrosidase (GBA) gene are the most common genetic risk factor for Parkinson disease (PD). These include pathogenic variants causing Gaucher disease (GD) (divided into “severe,” “mild,” or “complex”—resulting from recombinant alleles—based on the phenotypic effects in GD) and...

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Bibliographic Details
Main Authors: Elisa Menozzi, Anthony H. V. Schapira
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Neurology
Subjects:
Parkinson's
GBA
glucocerebrosidase
genotype-phenotype
biomarker
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2021.694764/full

Internet

https://www.frontiersin.org/articles/10.3389/fneur.2021.694764/full

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