Herpes Simplex Virus 1 Envelope Cholesterol Facilitates Membrane Fusion

Herpes Simplex Virus 1 Envelope Cholesterol Facilitates Membrane Fusion

Methyl beta-cyclodextrin (MβCD) treatment of herpes simplex virus 1 (HSV-1) reduced envelope cholesterol levels and inhibited viral entry and infectivity in several cell types, regardless of the dependence of entry on endocytosis or low pH. Viral protein composition was similar in MβCD-treated and u...

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Bibliographic Details
Main Authors: George A. Wudiri, Seth M. Schneider, Anthony V. Nicola
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Microbiology
Subjects:
herpesviruses
herpes simplex viruses
HSV-1
viral entry
membrane fusion
cholesterol
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.02383/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2017.02383/full

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