CPEB3 inhibits epithelial-mesenchymal transition by disrupting the crosstalk between colorectal cancer cells and tumor-associated macrophages via IL-6R/STAT3 signaling

CPEB3 inhibits epithelial-mesenchymal transition by disrupting the crosstalk between colorectal cancer cells and tumor-associated macrophages via IL-6R/STAT3 signaling

Abstract Background Crosstalk between cancer cells and tumor-associated macrophages (TAMs) mediates tumor progression in colorectal cancer (CRC). Cytoplasmic polyadenylation element binding protein 3 (CPEB3) has been shown to exhibit tumor-suppressive role in CRC. Methods The expression of CPEB3, CD...

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Bibliographic Details
Main Authors: Qian Zhong, Yuxin Fang, Qiuhua Lai, Shanci Wang, Chengcheng He, Aimin Li, Side Liu, Qun Yan
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Colorectal cancer
CPEB3
Cytoplasmic polyadenylation element binding protein 3
Tumor-associated macrophage
IL-6
EMT
Online Access:http://link.springer.com/article/10.1186/s13046-020-01637-4

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http://link.springer.com/article/10.1186/s13046-020-01637-4

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