Influence of Carrier (Polymer) Type and Drug-Carrier Ratio in the Development of Amorphous Dispersions for Solubility and Permeability Enhancement of Ritonavir

Influence of Carrier (Polymer) Type and Drug-Carrier Ratio in the Development of Amorphous Dispersions for Solubility and Permeability Enhancement of Ritonavir

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The influence of the ratio of Eudragit® L100-55 or Kolliphor® P188 on the solubility, dissolution, and permeability of ritonavir was studied with a goal of preparing solid dispersions (SDs) of ritonavir. SDs were formulated using solvent evaporation or lyophilization techniques, and evaluated for th...

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Bibliographic Details
Main Authors: Vivek S. Dave, Nishikant A. Raut, Deepak Gupta, Suprit D. Saoji, Pradip W. Dhore
Format: Article
Language:English
Published: International Pharmaceutical Excipients Council 2017-09-01
Series:Journal of Excipients and Food Chemicals
Subjects:
Ritonavir
solid-dispersion
solubility
dissolution
permeability
Online Access:https://jefc.scholasticahq.com/article/2579-influence-of-carrier-polymer-type-and-drug-carrier-ratio-in-the-development-of-amorphous-dispersions-for-solubility-and-permeability-enhancement-of-ritonavir

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https://jefc.scholasticahq.com/article/2579-influence-of-carrier-polymer-type-and-drug-carrier-ratio-in-the-development-of-amorphous-dispersions-for-solubility-and-permeability-enhancement-of-ritonavir

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